-Patients taking bupropion hydrochloride 300 mg orally per day during the autumn-winter season should have their dose tapered to 150 mg once a day for 2 weeks prior to discontinuation. -When discontinuing bupropion hydrobromide in patients treated with 348 mg orally once a day, the dose should be reduced to 174 mg once a day prior to discontinuation. Medscape - Depression, smoking cessation-specific dosing for Wellbutrin XL, Zyban (bupropion), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. Increase dose to 300 mg per day given as one 150-mg tablet twice each day with an interval of at least 8 hours between each dose. Do not exceed 300 mg per day. ZYBAN should be swallowed whole and not crushed, divided, or chewed, as this may lead to an increased risk of adverse effects including seizures [see Warnings and Precautions (5.3)]. Bupropion oral tablet is available as brand-name drugs and as generic drugs. Brand names: Wellbutrin SR, Wellbutrin XL, Aplenzin, Forfivo XL, and Zyban. Bupropion comes only as an immediate. Depression: 50-100 mg/day, Wellbutrin SR®: 100 mg/day or 150 mg every other day. The recommended dose for VIIBRYD is 40 mg once daily. The following information includes only the average doses of this medicine. A: Wellbutrin(bupropion hcl) dose have a generic form on the market. Check with your pharmacy about getting the generic version on the market. Co-p drugsays are usually much higher for brand name. The recommended dose as an aid for smoking cessation is 150 mg daily for 3 days, followed by 150 mg twice daily. You should start taking bupropion at least one week before stopping smoking. Treatment with bupropion is usually for 7 to 12 weeks. It is unknown whether the dose of WELLBUTRIN needed for maintenance treatment is identical to the dose that provided an initial response. Periodically reassess the need for maintenance treatment and the appropriate dose for such treatment. When used for smoking cessation, bupropion (Zyban) usually is started as 150 mg once daily for three days, and then the dose is increased to 150 mg twice daily for 7 to 12 weeks if the patient tolerates the starting dose.